RDH8 antibody (Middle Region)
RDH8
Reactivity: Human, Mouse, Pig, Rabbit, Rat, Cow, Dog, Guinea Pig, Horse
WB
Host: Rabbit
Polyclonal
unconjugated
1 image
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- Target See all RDH8 Antibodies
- RDH8 (Retinol Dehydrogenase 8 (RDH8))
- Binding Specificity
- Middle Region
- Reactivity
- Human, Mouse, Pig, Rabbit, Rat, Cow, Dog, Guinea Pig, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This RDH8 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- FDTNFFGAVR LVKAVLPGMK RRRQGHIVVI SSVMGLQGVI FNDVYAASKF
- Predicted Reactivity
- Cow: 93%, Dog: 92%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against RDH8. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of Human RDH8
- Top Product
- Discover our top product RDH8 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 311 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- RDH8 (Retinol Dehydrogenase 8 (RDH8))
- Alternative Name
- RDH8 (RDH8 Products)
- Background
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All-trans-retinol dehydrogenase (RDH8) is a visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol in the presence of NADPH (Rattner et al., 2000 [PubMed 10753906]). It is a member of the short chain dehydrogenase/reductase family and is located in the outer segments of photoreceptors, hence it is also known as photoreceptor retinol dehydrogenase. It is important in the visual cycle by beginning the rhodopsin regeneration pathway by reducing all-trans-retinal, the product of bleached and hydrolysed rhodopsin.
Alias Symbols: PRRDH, SDR28C2
Protein Size: 311 - Molecular Weight
- 34 kDa
- Gene ID
- 50700
- NCBI Accession
- NM_015725, NP_056540
- UniProt
- Q9NYR8
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