×
For best experience we recommend to activate Javascript in your browser.
DEF6 antibody (C-Term)
DEF6
Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-DEF6 Antibody
(hide)
Target
See all DEF6 Antibodies
DEF6
(Differentially Expressed in FDCP 6 Homolog (DEF6))
Binding Specificity
All epitopes for DEF6 antibodies
C-Term
Reactivity
All reactivities for DEF6 antibodies
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig
Host
All hosts for DEF6 antibodies
Rabbit
Clonality
All clonalities for DEF6 antibodies
Polyclonal
Conjugate
All conjugates for DEF6 antibodies
This DEF6 antibody is un-conjugated
Application
All applications for DEF6 antibodies
Western Blotting (WB)
Sequence
QERYIERAQQ EKEELQQEMA QQSRSLQQAQ QQLEEVRQNR QRADEDVEAA
Predicted Reactivity
Cow: 93%, Dog: 93%, Guinea Pig: 83%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 90%, Rabbit: 93%, Rat: 93%
Characteristics
This is a rabbit polyclonal antibody against DEF6. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of human BRCC3
Top Product
Discover our top product DEF6 Primary Antibody
Alternatives
(show)
Application Details
(hide)
Restrictions
For Research Use only
Handling
(hide)
Format
Liquid
Concentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeat freeze-thaw cycles.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for DEF6
(hide)
Target
DEF6
(Differentially Expressed in FDCP 6 Homolog (DEF6))
Alternative Name
DEF6 (DEF6 Products )
Synonyms
DEF6 antibody, Def6 antibody, zgc:63721 antibody, ibp antibody, slat antibody, swap70l antibody, MGC68775 antibody, 2410003F05Rik antibody, 6430538D02Rik antibody, AV094905 antibody, Ibp antibody, Slat antibody, Slat2 antibody, Slat6 antibody, IBP antibody, SLAT antibody, SWAP70L antibody, DEF6, guanine nucleotide exchange factor antibody, differentially expressed in FDCP 6a homolog (mouse) antibody, DEF6, guanine nucleotide exchange factor L homeolog antibody, differentially expressed in FDCP 6 antibody, DEF6 guanine nucleotide exchange factor antibody, DEF6 antibody, def6a antibody, def6.L antibody, def6 antibody, Def6 antibody
Background
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. Alias Symbols: C6.1A, BRCC36, CXorf53 Protein Size: 376
Molecular Weight
41 kDa
Gene ID
79184
NCBI Accession
NM_001018055 , NP_001018065
UniProt
P46736
Recently viewed
(hide)