MASP1 antibody (N-Term)
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- Target See all MASP1 Antibodies
- MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))
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Binding Specificity
- N-Term
- Reactivity
- Human, Mouse, Rat, Rabbit, Guinea Pig, Cow, Dog, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MASP1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- PGSFMSITFR SDFSNEERFT GFDAHYMAVD VDECKEREDE ELSCDHYCHN
- Predicted Reactivity
- Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against MASP1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human MASP1
- Top Product
- Discover our top product MASP1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 699 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))
- Alternative Name
- MASP1 (MASP1 Products)
- Synonyms
- AW048060 antibody, CCPII antibody, Crarf antibody, Masp1/3 antibody, 3MC1 antibody, CRARF antibody, CRARF1 antibody, MAP1 antibody, MASP antibody, MASP3 antibody, MAp44 antibody, PRSS5 antibody, RaRF antibody, mannan-binding lectin serine peptidase 1 antibody, mannan binding lectin serine peptidase 1 antibody, Masp1 antibody, MASP1 antibody
- Background
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This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway.
Alias Symbols: CRARF, CRARF1, DKFZp686I01199, FLJ26383, MASP, MGC126283, MGC126284, PRSS5, RaRF
Protein Interaction Partner: CDK19, CUL3, PDCD6IP, RPS6KA6, MAPK8IP2, NUDT21, NCK2, UFD1L, RPS6KA3, MAPK6, H2AFX, GSK3B, GADD45A, C2, SERPING1, FCN2, MBL2, C3, MASP2,
Protein Size: 699 - Molecular Weight
- 28 kDa
- Gene ID
- 5648
- NCBI Accession
- NM_001879, NP_001870
- UniProt
- P48740
- Pathways
- Complement System
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