RASGRP1 antibody (C-Term)

Catalog No. ABIN2789624

Product Details anti-RASGRP1 Antibody

Target: RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))

Binding Specificity: C-Term

Reactivity: Human, Guinea Pig, Mouse, Rabbit, Cow, Dog, Horse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RASGRP1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LGAKDLLHAP EEGPFTFPNG EAVEHGEESK DRTIMLMGVS SQKISLRLKR

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 79%, Rabbit: 79%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against RASGRP1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 797 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RASGRP1

Target: RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))

Alternative Name: RASGRP1 (RASGRP1 Products)

Synonyms: Rasgrp antibody, CALDAG-GEFI antibody, CALDAG-GEFII antibody, RASGRP antibody, V antibody, hRasGRP1 antibody, RAS guanyl releasing protein 1 antibody, Rasgrp1 antibody, RASGRP1 antibody

Background: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).
Alias Symbols: CALDAG-GEFI, CALDAG-GEFII, MGC129998, MGC129999, RASGRP, V, hRasGRP1
Protein Interaction Partner: Dlg4, ABCB8, DGKZ, HRAS, VHL, PPM1B,
Protein Size: 797

Molecular Weight: 90 kDa

Gene ID: 10125

NCBI Accession: NM_005739, NP_005730

UniProt: O95267

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway