SOCS2 antibody (C-Term)

Catalog No. ABIN2789498

Product Details anti-SOCS2 Antibody

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse, Pig, Cow, Dog, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KQFDSVVHLI DYYVQMCKDK RTGPEAPRNG TVHLYLTKPL YTSAPSLQHL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SOCS2. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 198 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SOCS2

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Alternative Name: SOCS2 (SOCS2 Products)

Synonyms: CIS2 antibody, Cish2 antibody, SOCS-2 antibody, SSI-2 antibody, SSI2 antibody, STATI2 antibody, Cish1 antibody, Socs-1 antibody, Socs-2 antibody, si:dkey-202b22.1 antibody, socs2 antibody, cis2 antibody, ssi2 antibody, cish2 antibody, ssi-2 antibody, socs-2 antibody, stati2 antibody, 8030460M17 antibody, AI527257 antibody, AW108012 antibody, D130043N08Rik antibody, JAB antibody, hg antibody, Cradd antibody, Socs2 antibody, suppressor of cytokine signaling 2 antibody, suppressor of cytokine signaling 1 antibody, death domain-containing protein CRADD antibody, suppressor of cytokine signaling 2 S homeolog antibody, SOCS2 antibody, Socs1 antibody, Socs2 antibody, socs2 antibody, LOC100716104 antibody, socs2.S antibody

Background: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.
Alias Symbols: CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2
Protein Interaction Partner: Tceb1, CUL5, UBC, FLT3, ARFIP2, TPD52, PLA2G1B, BMI1, SOCS3, LCK, GHR, CCNC, RYBP, PTK2B, RNF7, TCEB2, EPOR, PTK2, PRLR, INSR, IGF1R, SOCS1,
Protein Size: 198

Molecular Weight: 22 kDa

Gene ID: 8835

NCBI Accession: NM_003877, NP_003868

UniProt: O14508

Pathways: JAK-STAT Signaling, Response to Growth Hormone Stimulus