HLA-DMB antibody (N-Term)
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- Target See all HLA-DMB Antibodies
- HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))
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Binding Specificity
- N-Term
- Reactivity
- Human, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This HLA-DMB antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- FTYCISFNKD LLTCWDPEEN KMAPCEFGVL NSLANVLSQH LNQKDTLMQR
- Predicted Reactivity
- Human: 100%, Rat: 86%
- Characteristics
- This is a rabbit polyclonal antibody against HLA-DMB. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product HLA-DMB Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 263 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))
- Alternative Name
- HLA-DMB (HLA-DMB Products)
- Synonyms
- RING7 antibody, D6S221E antibody, RT1.DMb antibody, RT1.Mb antibody, MHC-DMB antibody, major histocompatibility complex, class II, DM beta antibody, RT1 class II, locus DMb antibody, HLA-DMB antibody, RT1-DMb antibody, PATR-DMB antibody
- Background
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HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
Alias Symbols: D6S221E, RING7
Protein Interaction Partner: CUL3, TEAD1, MDM2, DPM2, CD82, HLA-DOB, CD63, HLA-DRA, HLA-DMA, CD74,
Protein Size: 263 - Molecular Weight
- 29 kDa
- Gene ID
- 3109
- NCBI Accession
- NM_002118, NP_002109
- UniProt
- P28068
- Pathways
- Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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