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SMN2 antibody (N-Term)

SMN2 Reactivity: Human, Mouse, Pig, Rabbit, Dog, Goat, Horse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2789459
  • Target See all SMN2 Antibodies
    SMN2 (Survival of Motor Neuron 2, Centromeric (SMN2))
    Binding Specificity
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    Human, Mouse, Pig, Rabbit, Dog, Goat, Horse
    Host
    • 6
    • 5
    Rabbit
    Clonality
    • 8
    • 3
    Polyclonal
    Conjugate
    • 11
    This SMN2 antibody is un-conjugated
    Application
    • 9
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    KHALKNGDIC ETSGKPKTTP KRKPAKKNKS QKKNTAASLQ QWKVGDKCSA
    Predicted Reactivity
    Dog: 93%, Goat: 82%, Horse: 92%, Human: 100%, Mouse: 79%, Pig: 86%, Rabbit: 85%
    Characteristics
    This is a rabbit polyclonal antibody against SMN2. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N-terminal region of SMN2
    Top Product
    Discover our top product SMN2 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 250 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    SMN2 (Survival of Motor Neuron 2, Centromeric (SMN2))
    Alternative Name
    SMN2 (SMN2 Products)
    Synonyms
    BCD541 antibody, C-BCD541 antibody, GEMIN1 antibody, SMNC antibody, TDRD16B antibody, bcd541 antibody, c-bcd541 antibody, gemin-1 antibody, smn2 antibody, smnc antibody, survival of motor neuron 2, centromeric antibody, survival of motor neuron 2, centromeric L homeolog antibody, SMN2 antibody, smn2.L antibody
    Background
    This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. While mutations in the telomeric copy are associated with spinal muscular atrophy, mutations in this gene, the centromeric copy, do not lead to disease. This gene may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The full length protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Four transcript variants encoding distinct isoforms have been described.
    Alias Symbols: BCD541, C-BCD541, FLJ76644, MGC20996, MGC5208, SMN1, SMNC
    Protein Interaction Partner: FAM9B, VPS28, BLOC1S6, CHTOP, HNRNPUL1, POLR1C, PPIG, SMN2, BYSL, WWOX, vpr, UBC, SMN1, RBM25, DDX20, COIL, SRSF5, CUL3, POLR2A, GAR1, SNRPG, SNRPF, SNRPB2, TIAL1, DHX9, GEMIN2, SNRPD1, SNRPD3, SNRPD2, SNRPB, FBL, SNRPE, LRIF1, OSTF1, COPS6, LENG8, STXBP3
    Protein Size: 250
    Molecular Weight
    27 kDa
    Gene ID
    6607
    NCBI Accession
    NM_022877, NP_075015
    UniProt
    Q16637
    Pathways
    Ribonucleoprotein Complex Subunit Organization
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