VKORC1 antibody (N-Term)

Catalog No. ABIN2789450

Product Details anti-VKORC1 Antibody

Target: VKORC1 (Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VKORC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: LHVKAARARD RDYRALCDVG TAISCSRVFS SRLPADTLGL CPDAAELPGV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against VKORC1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of VKORC1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 92 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for VKORC1

Target: VKORC1 (Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1))

Alternative Name: VKORC1 (VKORC1 Products)

Background: Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described.
Alias Symbols: EDTP308, FLJ00289, IMAGE3455200, MGC2694, MST134, MST576, VKCFD2, VKOR
Protein Interaction Partner: UBC, ILK, ZMYM6NB, TMEM242, SNORA12, TMEM256, ZCCHC24, METTL7B, SPTSSA, VKORC1L1, CCDC167, CCDC12, TMEM45B, KCNK17, JAGN1, SERP1, PPA2, TRAM1, TREX1, YIF1A, EBP, ARL6IP5, PROCR, IFITM3, ATP6AP2, BCAP31, PDIA6, HDAC6, HOMER2, VAPB, CLDN10, DPM2, REEP5, TF,
Protein Size: 92

Molecular Weight: 10 kDa

Gene ID: 79001

NCBI Accession: NM_206824, NP_996560

UniProt: Q9BQB6