MC1 Receptor antibody (C-Term)
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- Target See all MC1 Receptor (MC1R) Antibodies
- MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))
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Binding Specificity
- C-Term
- Reactivity
- Human, Mouse, Rat, Pig, Rabbit
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MC1 Receptor antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- CPEHPTCGCI FKNFNLFLAL IICNAIIDPL IYAFHSQELR RTLKEVLTCS
- Predicted Reactivity
- Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 93%, Rat: 93%
- Characteristics
- This is a rabbit polyclonal antibody against MC1R. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C-terminal region of MC1R
- Top Product
- Discover our top product MC1R Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 317 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))
- Alternative Name
- MC1R (MC1R Products)
- Synonyms
- CMM5 antibody, MSH-R antibody, SHEP2 antibody, Mshra antibody, Tob antibody, e antibody, MC1-R antibody, MSHR antibody, mc1r antibody, MC1R antibody, TUBB3 antibody, melanocortin 1 receptor antibody, melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) antibody, MC1R antibody, Mc1r antibody, mc1r antibody, mc1r_par1 antibody
- Background
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This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
Alias Symbols: CMM5, MGC14337, MSH-R, SHEP2
Protein Interaction Partner: SUMO2, RIC8A, OGFOD1, TRNT1, EZR, UBA1, PYGL, AHCY, UBC, MGRN1, ASIP, POMC, MC4R,
Protein Size: 317 - Molecular Weight
- 35 kDa
- Gene ID
- 4157
- NCBI Accession
- NM_002386, NP_002377
- UniProt
- Q01726
- Pathways
- cAMP Metabolic Process, Feeding Behaviour
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