Merlin antibody (C-Term)

Catalog No. ABIN2789402

Product Details anti-Merlin Antibody

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Dog, Cow, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Merlin antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MAEESERRAK EADQLKQDLQ EAREAERRAK QKLLEIATKP TYPPMNPIPA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against NF2. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 507 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-Merlin antibody (ABIN2789402)

Vasilyeva, Murzina, Kireev, Pivovarov: "Influence of Membrane Receptor Lateral Diffusion on the Short-Term Depression of Acetylcholine-Induced Current in Helix Neurons." in: Cellular and molecular neurobiology, (2017) (PubMed).

Target Details for Merlin

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Alternative Name: NF2 (NF2 Products)

Synonyms: ACN antibody, BANF antibody, SCH antibody, NF2 antibody, merlin antibody, zgc:194620 antibody, zgc:194631 antibody, NF2a antibody, nf2 antibody, neurofibromin 2 antibody, neurofibromin 2a (merlin) antibody, neurofibromin 2b (merlin) antibody, neurofibromin 2 (merlin) S homeolog antibody, NF2 antibody, Nf2 antibody, nf2a antibody, nf2b antibody, nf2.S antibody

Background: This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development, in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
Alias Symbols: ACN, BANF, SCH
Protein Interaction Partner: VPRBP, CD44, UBC, KDM1A, AMOTL2, YAP1, PPP1R8, UBD, CCNB1IP1, HGS, CUL4A, DDB1, GPS1, WWC1, PYGO2, AMOT, SCHIP1, SGSM3, NF2, TSC1, TARBP2, SLC9A3R1, PAK1, XPO1, PXN, SDCBP, RALGDS, SPTBN1, ERBB2, ITGB1, EZR, CTNNB1, AGAP2, AKT1, RIT1, ARHGAP32, SOS1, MED2
Protein Size: 507

Molecular Weight: 56 kDa

Gene ID: 4771

NCBI Accession: NM_181830, NP_861968

Pathways: Cell-Cell Junction Organization