CD33 antibody (N-Term)
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- Target See all CD33 Antibodies
- CD33
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Binding Specificity
- N-Term
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Reactivity
- Human, Cow, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CD33 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- HPIPYYDKNS PVHGYWFREG AIISRDSPVA TNKLDQEVQE ETQGRFRLLG
- Predicted Reactivity
- Cow: 79%, Horse: 79%, Human: 100%
- Characteristics
- This is a rabbit polyclonal antibody against CD33. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product CD33 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 364 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- CD33
- Alternative Name
- CD33 (CD33 Products)
- Synonyms
- SIGLEC-3 antibody, SIGLEC3 antibody, p67 antibody, Siglec-3 antibody, gp67 antibody, CD33 molecule antibody, CD33 antigen antibody, CD33 antibody, Cd33 antibody
- Background
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CD33 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 induces apoptosis in acute myeloid leukemia (in vitro).
Alias Symbols: FLJ00391, SIGLEC-3, SIGLEC3, p67
Protein Interaction Partner: KRT40, KRT31, HERC3, UBC, CBL, SRC, PTPN6, PTPN11,
Protein Size: 364 - Molecular Weight
- 38 kDa
- Gene ID
- 945
- NCBI Accession
- NM_001772, NP_001763
- UniProt
- P20138
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