HLA-E antibody (C-Term)
-
- Target See all HLA-E Antibodies
- HLA-E (HLA Class I Histocompatibility Antigen, alpha Chain E (HLA-E))
-
Binding Specificity
- C-Term
-
Reactivity
- Human, Mouse, Pig
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This HLA-E antibody is un-conjugated
-
Application
- Western Blotting (WB)
- Sequence
- IPIVGIIAGL VLLGSVVSGA VVAAVIWRKK SSGGKGGSYS KAEWSDSAQG
- Predicted Reactivity
- Human: 100%, Mouse: 100%, Pig: 92%
- Characteristics
- This is a rabbit polyclonal antibody against HLA-E. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product HLA-E Primary Antibody
-
-
- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
-
Antigen size: 358 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- HLA-E (HLA Class I Histocompatibility Antigen, alpha Chain E (HLA-E))
- Alternative Name
- HLA-E (HLA-E Products)
- Synonyms
- EA1.2 antibody, EA2.1 antibody, HLA-6.2 antibody, MHC antibody, QA1 antibody, major histocompatibility complex, class I, E antibody, HLA-E antibody, PATR-E antibody
- Background
-
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.
Alias Symbols: DKFZp686P19218, EA1.2, EA2.1, HLA-6.2, MHC, QA1
Protein Interaction Partner: UBC, CALR, TAP2, UBD, PPP1R16A, KLRD1, KLRC2, CD8A, KLRC1, HLA-E, B2M,
Protein Size: 358 - Molecular Weight
- 38 kDa
- Gene ID
- 3133
- NCBI Accession
- NM_005516, NP_005507
- UniProt
- P13747
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
-