FPGT antibody (C-Term)

Catalog No. ABIN2789256

Product Details anti-FPGT Antibody

Target: FPGT (Fucose-1-Phosphate Guanylyltransferase (FPGT))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Guinea Pig, Cow, Dog, Pig, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FPGT antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TSLNVVVLNN SKFYHIGTTE EYLFYFTSDN SLKSELGLQS ITFSIFPDIP

Predicted Reactivity: Cow: 86%, Dog: 86%, Guinea Pig: 86%, Human: 100%, Mouse: 79%, Pig: 100%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against FPGT. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human FPGT

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 594 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FPGT

Target: FPGT (Fucose-1-Phosphate Guanylyltransferase (FPGT))

Alternative Name: FPGT (FPGT Products)

Background: L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose, the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene.
Alias Symbols: GFPP
Protein Interaction Partner: NLN,
Protein Size: 594

Molecular Weight: 66 kDa

Gene ID: 8790

NCBI Accession: NM_003838, NP_003829

UniProt: O14772