EIF3A antibody (C-Term)

Catalog No. ABIN2788872

Product Details anti-EIF3A Antibody

Target: EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Horse, Zebrafish (Danio rerio), Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF3A antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PPALSRDRER DRDREREGEK EKASWRAEKD RESLRRTKNE TDEDGWTTVR

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against EIF3A. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1382 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for EIF3A

Target: EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A))

Alternative Name: EIF3A (EIF3A Products)

Synonyms: EIF3 antibody, EIF3S10 antibody, P167 antibody, TIF32 antibody, eIF3-p170 antibody, eIF3-theta antibody, p180 antibody, p185 antibody, EIF6 antibody, A830012B05Rik antibody, Csma antibody, Eif3 antibody, Eif3s10 antibody, mKIAA0139 antibody, ZH12 antibody, eif3s10 antibody, eIF3 p110 antibody, eIF3a antibody, eukaryotic translation initiation factor 3 subunit A antibody, eukaryotic translation initiation factor 3, subunit A antibody, eukaryotic translation initiation factor 3 subunit A S homeolog antibody, translation initiation factor eIF3a antibody, EIF3A antibody, Eif3a antibody, eif3a.S antibody, tif32 antibody

Background: EIF3A is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Alias Symbols: EIF3, EIF3S10, KIAA0139, P167, TIF32, eIF3-p170, eIF3-theta, p180, p185
Protein Interaction Partner: UBC, REL, TFIP11, WWP2, SUMO2, STAU1, LGR4, WWOX, EED, SHFM1, RNF2, EIF3CL, YTHDF2, LARP1, NUDT21, EIF3C, DYNC1I2, RPS26, RPS25, RPS23, RPS20, RPS18, RPS12, RPS10, RPS9, RPS3A, RPS3, FBXO6, TARDBP, EIF3D, UBD, ICAM1, CD81, RIOK2, IGSF8, BBS4, BBS1, gag-po
Protein Size: 1382

Molecular Weight: 152 kDa

Gene ID: 8661

NCBI Accession: NM_003750, NP_003741

UniProt: Q14152

Pathways: Ribonucleoprotein Complex Subunit Organization