GALR2 antibody (C-Term)
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- Target See all GALR2 Antibodies
- GALR2 (Galanin Receptor 2 (GALR2))
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Binding Specificity
- C-Term
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Reactivity
- Human, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This GALR2 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- RGTHSGSVLE RESSDLLHMS EAAGALRPCP GASQPCILEP CPGPSWQGPK
- Predicted Reactivity
- Horse: 93%, Human: 100%
- Characteristics
- This is a rabbit polyclonal antibody against GALR2. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product GALR2 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 387 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- GALR2 (Galanin Receptor 2 (GALR2))
- Alternative Name
- GALR2 (GALR2 Products)
- Synonyms
- GALNR2 antibody, mGalR antibody, GALR2 antibody, GAL2-R antibody, GALR-2 antibody, galanin receptor 2 antibody, transcription regulator. LacI family, raffinose related antibody, DNA-binding transcriptional regulator GalR antibody, galactose operon repressor antibody, galanin receptor type 2 antibody, GALR2 antibody, Galr2 antibody, LOC100037698 antibody, rafR antibody, galR2 antibody, LOC103690156 antibody
- Background
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Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.
Alias Symbols: GALNR2, MGC125983, MGC125984
Protein Interaction Partner: GNAQ, GAL,
Protein Size: 387 - Molecular Weight
- 43 kDa
- Gene ID
- 8811
- NCBI Accession
- NM_003857, NP_003848
- UniProt
- O43603
- Pathways
- cAMP Metabolic Process, Inositol Metabolic Process, Feeding Behaviour
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