HIST1H2AE antibody (Middle Region)

Catalog No. ABIN2788645

Product Details anti-HIST1H2AE Antibody

Target: HIST1H2AE (Histone Cluster 1, H2ae (HIST1H2AE))

Binding Specificity: Middle Region

Reactivity: Human, Cow, Rat, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HIST1H2AE antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TAEILELAGN AARDNKKTRI IPRHLQLAIR NDEELNKLLG RVTIAQGGVL

Predicted Reactivity: Cow: 100%, Human: 100%, Pig: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against HIST1H2AE. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 130 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HIST1H2AE

Target: HIST1H2AE (Histone Cluster 1, H2ae (HIST1H2AE))

Alternative Name: HIST1H2AE (HIST1H2AE Products)

Synonyms: H2A.1 antibody, H2A.2 antibody, H2A/a antibody, H2AFA antibody, histone cluster 1 H2A family member e antibody, HIST1H2AE antibody

Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails, instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.
Alias Symbols: H2A.1, H2A.2, H2A/a, H2AFA, HIST1H2AB
Protein Interaction Partner: UBC, HUWE1, SUZ12, EZH2, ITGA4, CAND1, COPS5, CUL1, CUL4A, CUL4B, CUL5, NFX1, NEDD8, TONSL, SUMO1, EID1, UHRF1, NAP1L4,
Protein Size: 130

Molecular Weight: 14 kDa

Gene ID: 3012

NCBI Accession: NM_021052, NP_066390

UniProt: Q7L7L0

Pathways: Telomere Maintenance