Histone Cluster 2, H4a (HIST2H4A) (Middle Region) antibody

Catalog No. ABIN2788644

Product Details

Target: Histone Cluster 2, H4a (HIST2H4A)

Binding Specificity: Middle Region

Reactivity: Rat, Mouse, Zebrafish (Danio rerio), Cow, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Sequence: LARRGGVKRI SGLIYEETRG VLKVFLENVI RDAVTYTEHA KRKTVTAMDV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against Hist2h4. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 103 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details

Target: Histone Cluster 2, H4a (HIST2H4A)

Alternative Name: Hist2h4 (HIST2H4A Products)

Synonyms: FO108 antibody, H4 antibody, H4/n antibody, H4F2 antibody, H4FN antibody, HIST2H4 antibody, X04652 antibody, Hist4h4 antibody, histone cluster 2 H4 family member a antibody, histone cluster 2, H4 antibody, histone H4 antibody, HIST2H4A antibody, Hist2h4 antibody, HIST2H4 antibody

Background: Hist2h4 is a core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Alias Symbols: H4, X04652
Protein Interaction Partner: Csrp2bp, Wdtc1, Myocd, Zbtb16, Tcf3,
Protein Size: 103

Molecular Weight: 11 kDa

Gene ID: 97122

NCBI Accession: NM_033596, NP_291074

UniProt: P62806

Pathways: Telomere Maintenance