CYP21A2 antibody (C-Term)
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- Target See all CYP21A2 Antibodies
- CYP21A2 (Cytochrome P450, Family 21, Subfamily A, Polypeptide 2 (CYP21A2))
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Binding Specificity
- C-Term
- Reactivity
- Human, Sheep, Cow, Dog, Guinea Pig, Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CYP21A2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- IQQRLQEELD HELGPGASSS RVPYKDRARL PLLNATIAEV LRLRPVVPLA
- Predicted Reactivity
- Cow: 92%, Dog: 92%, Guinea Pig: 80%, Human: 100%, Pig: 92%, Sheep: 92%
- Characteristics
- This is a rabbit polyclonal antibody against CYP21A2. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human CYP21A2
- Top Product
- Discover our top product CYP21A2 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 495 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- CYP21A2 (Cytochrome P450, Family 21, Subfamily A, Polypeptide 2 (CYP21A2))
- Alternative Name
- CYP21A2 (CYP21A2 Products)
- Synonyms
- CA21H antibody, CAH1 antibody, CPS1 antibody, CYP21 antibody, CYP21B antibody, P450c21B antibody, 21-OH antibody, 21OH antibody, 21OHA antibody, 21OHB antibody, CYP21OH-A antibody, Cyp21 antibody, Cyp21-ps1 antibody, Cyp21B antibody, Cyp21a2-ps antibody, Cyp21a2ps antibody, Oh21-1 antibody, Oh21-2 antibody, CYP21A antibody, 21-OHase antibody, cytochrome P450 family 21 subfamily A member 2 antibody, cytochrome P450, family 21, subfamily a, polypeptide 1 antibody, cytochrome P450c21 antibody, cytochrome P450, family 21, subfamily A, polypepide 2 antibody, cytochrome P450, family 21, subfamily A, polypeptide 2 antibody, steroid 21-hydroxylase-like antibody, CYP21A2 antibody, Cyp21a1 antibody, LOC101094596 antibody
- Background
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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene, gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: CA21H, CAH1, CPS1, CYP21, CYP21B, MGC150536, MGC150537, P450c21B
Protein Size: 495 - Molecular Weight
- 56 kDa
- Gene ID
- 1589
- NCBI Accession
- NM_000500, NP_000491
- UniProt
- Q16874
- Pathways
- Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process
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