CTSC antibody (Middle Region)

Catalog No. ABIN2788336

Product Details anti-CTSC Antibody

Target: CTSC (Cathepsin C (CTSC))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Cow, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTSC antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: WTATTYMEYE TLTLGDMIRR SGGHSRKIPR PKPAPLTAEI QQKILHLPTS

Predicted Reactivity: Cow: 86%, Dog: 79%, Horse: 86%, Human: 100%, Mouse: 79%

Characteristics: This is a rabbit polyclonal antibody against CTSC. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CTSC

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 463 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CTSC

Target: CTSC (Cathepsin C (CTSC))

Alternative Name: CTSC (CTSC Products)

Background: CTSC is a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in CTSC have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.
Alias Symbols: CPPI, DPP1, DPPI, HMS, JP, JPD, PALS, PLS, DPP-I
Protein Interaction Partner: SUMO1, UBC, NEDD8, ARMC9, ANKMY2, ARIH1, UBA2, ADSL, FBXO6, XRN2, CAPN1, CD81, CTSC, CTSL,
Protein Size: 463

Molecular Weight: 8 kDa

Gene ID: 1075

NCBI Accession: NM_001814, NP_001805

UniProt: P53634