MRPL49 antibody (N-Term)

Catalog No. ABIN2788326

Product Details anti-MRPL49 Antibody

Target: MRPL49 (Mitochondrial Ribosomal Protein L49 (MRPL49))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MRPL49 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ESVDEYQFVE RLLPATRIPD PPKHEHYPTP SGWQPPRDPP PNLPYFVRRS

Predicted Reactivity: Cow: 86%, Dog: 86%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Mouse: 79%, Rabbit: 83%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against MRPL49. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MRPL49

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 166 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MRPL49

Target: MRPL49 (Mitochondrial Ribosomal Protein L49 (MRPL49))

Alternative Name: MRPL49 (MRPL49 Products)

Synonyms: Aa2-277 antibody, BcDNA:RE35556 antibody, CG4647 antibody, Dmel\\CG4647 antibody, MRP-L49 antibody, mRpl49 antibody, C11orf4 antibody, L49mt antibody, NOF antibody, NOF1 antibody, 4833419D18Rik antibody, Nof1 antibody, mitochondrial ribosomal protein L49 antibody, Mrpl49 antibody, mRpL49 antibody, MRPL49 antibody

Background: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75 % protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene and the gene for the HRD1 protein use in their respective 3' UTRs some of the same genomic sequence. Pseudogenes corresponding to this gene are found on chromosomes 5q and 8p.
Alias Symbols: C11orf4, L49mt, MGC10656, NOF, NOF1, MRP-L49
Protein Interaction Partner: CEP57, NPM1, METTL18, MRPL52, PRKCDBP, TMEM177, MRPL38, MRPL39, NENF, TIMM10, SCFD1, PPT2, MTHFD1, MGST3, DLST, CDH2, APP, CAND1, COPS5, CUL1, CUL3, TCF3, UBC, ICT1, OXA1L,
Protein Size: 166

Molecular Weight: 19 kDa

Gene ID: 740

NCBI Accession: NM_004927, NP_004918

UniProt: Q13405