CMA1 antibody (C-Term)
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- Target See all CMA1 Antibodies
- CMA1 (Chymase 1, Mast Cell (CMA1))
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Binding Specificity
- C-Term
- Reactivity
- Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Sheep
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CMA1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- EVKLRLMDPQ ACSHFRDFDH NLQLCVGNPR KTKSAFKGDS GGPLLCAGVA
- Predicted Reactivity
- Cow: 86%, Dog: 100%, Guinea Pig: 86%, Human: 100%, Mouse: 79%, Rabbit: 79%, Rat: 86%, Sheep: 86%
- Characteristics
- This is a rabbit polyclonal antibody against CMA1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human CMA1
- Top Product
- Discover our top product CMA1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 247 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- CMA1 (Chymase 1, Mast Cell (CMA1))
- Alternative Name
- CMA1 (CMA1 Products)
- Synonyms
- CYH antibody, MCT1 antibody, chymase antibody, MMCP-5 antibody, Mcp-5 antibody, Mcp5 antibody, Mcpt5 antibody, MCP3P antibody, CMA1 antibody, Chymase antibody, chymase 1 antibody, chymase 1, mast cell antibody, chymase-like antibody, CMA1 antibody, Cma1 antibody, LOC100008644 antibody
- Background
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CMA1 is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies.
Alias Symbols: CYH, MCT1, MGC119890, MGC119891, chymase
Protein Interaction Partner: FYN, IL1B, EDN2, EDN1, KITLG, PFN1, EDN3, MMP1, SERPINA3, AGT,
Protein Size: 247 - Molecular Weight
- 27 kDa
- Gene ID
- 1215
- NCBI Accession
- NM_001836, NP_001827
- UniProt
- P23946
- Pathways
- ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Carbohydrate Homeostasis
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