BBS10 antibody (C-Term)

Catalog No. ABIN2788220

Product Details anti-BBS10 Antibody

Target: BBS10 (Bardet-Biedl Syndrome 10 (BBS10))

Binding Specificity: C-Term

Reactivity: Human, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BBS10 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SQTGLESVMG KYQLLTSVLQ CLTKILTIDM VITVKRHPQK VHNQDSEDEL

Predicted Reactivity: Human: 100%, Rabbit: 86%

Characteristics: This is a rabbit polyclonal antibody against BBS10. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human BBS10

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 723 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for BBS10

Target: BBS10 (Bardet-Biedl Syndrome 10 (BBS10))

Alternative Name: BBS10 (BBS10 Products)

Synonyms: MGC84945 antibody, si:dkey-30c15.16 antibody, C12orf58 antibody, RGD1560748 antibody, 1300007O09Rik antibody, AI452285 antibody, Bardet-Biedl syndrome 10 antibody, Bardet-Biedl syndrome 10 L homeolog antibody, Bardet-Biedl syndrome 10 (human) antibody, BBS10 antibody, bbs10.L antibody, bbs10 antibody, Bbs10 antibody

Background: This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes. Mutations in this gene cause Bardet-Biedl syndrome type 10.
Alias Symbols: C12orf58, FLJ23560
Protein Interaction Partner: UBC, YAE1D1, MAPK8IP2, HDAC6, TNFSF11, MAP3K7, RGS2, RASA1, PTK2, MAPK6, NR4A1, FRZB, CSNK1E,
Protein Size: 723

Molecular Weight: 81 kDa

Gene ID: 79738

NCBI Accession: NM_024685, NP_078961

UniProt: Q8TAM1