COCH antibody (C-Term)

Catalog No. ABIN2788126

Product Details anti-COCH Antibody

Target: COCH (Cochlin (COCH))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COCH antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VAWAPLDDLK DMASKPKESH AFFTREFTGL EPIVSDVIRG ICRDFLESQQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against COCH. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human COCH

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 550 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for COCH

Target: COCH (Cochlin (COCH))

Alternative Name: COCH (COCH Products)

Synonyms: AW122937 antibody, Coch-5B2 antibody, D12H14S564E antibody, COCH-5B2 antibody, COCH5B2 antibody, DFNA9 antibody, cochlin antibody, Coch antibody, COCH antibody

Background: The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94 % and 79 % amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.
Alias Symbols: COCH-5B2, COCH5B2, DFNA9
Protein Interaction Partner: FBXO6,
Protein Size: 550

Molecular Weight: 57 kDa

Gene ID: 1690

NCBI Accession: NM_001135058, NP_001128530

UniProt: O43405

Pathways: Sensory Perception of Sound