USP10 antibody (C-Term)
-
- Target See all USP10 Antibodies
- USP10 (Ubiquitin Specific Peptidase 10 (USP10))
-
Binding Specificity
- C-Term
-
Reactivity
- Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This USP10 antibody is un-conjugated
-
Application
- Western Blotting (WB)
- Sequence
- RDIRPGAAFE PTYIYRLLTV IKSSLSEKGR QEDAEEYLGF ILNGLHEEML
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
- Characteristics
- This is a rabbit polyclonal antibody against Usp10. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product USP10 Primary Antibody
-
-
- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
-
Antigen size: 794 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- USP10 (Ubiquitin Specific Peptidase 10 (USP10))
- Alternative Name
- Usp10 (USP10 Products)
- Synonyms
- T4F9.30 antibody, T4F9_30 antibody, ubiquitin-specific protease 9 antibody, ubpo antibody, USP10 antibody, id:ibd1190 antibody, wu:fc19h08 antibody, wu:fc76g05 antibody, wu:fi11g01 antibody, UBPO antibody, 2610014N07Rik antibody, Uchrp antibody, mKIAA0190 antibody, usp10-A antibody, ubiquitin specific peptidase 10 antibody, universal stress protein UspA antibody, ubiquitin-specific protease 9 antibody, ubiquitin carboxyl-terminal hydrolase 10 antibody, ubiquitin specific peptidase 10 S homeolog antibody, USP10 antibody, RR_RS14970 antibody, UBP9 antibody, PTRG_07201 antibody, MGYG_06403 antibody, usp10 antibody, Usp10 antibody, usp10.S antibody
- Background
-
Usp10 is a hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, SNX3 and CFTR. It acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Usp10 does not deubiquitinate MDM2 and deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling.
Alias Symbols: MGC124997
Protein Size: 794 - Molecular Weight
- 87 kDa
- Gene ID
- 307905
- NCBI Accession
- NM_001034146, NP_001029318
- UniProt
- Q3KR59
-