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USP8 antibody (C-Term)

USP8 Reactivity: Human, Mouse, Rat, Pig, Cow, Dog, Horse, Rabbit, Zebrafish (Danio rerio), Guinea Pig WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2788008
  • Target See all USP8 Antibodies
    USP8 (Ubiquitin Specific Peptidase 8 (USP8))
    Binding Specificity
    • 8
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    Human, Mouse, Rat, Pig, Cow, Dog, Horse, Rabbit, Zebrafish (Danio rerio), Guinea Pig
    Host
    • 32
    • 2
    • 1
    Rabbit
    Clonality
    • 33
    • 2
    Polyclonal
    Conjugate
    • 25
    • 2
    • 2
    • 2
    • 2
    • 2
    This USP8 antibody is un-conjugated
    Application
    • 31
    • 15
    • 12
    • 6
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    FAGYSQQDSQ ELLLFLMDGL HEDLNKADNR KRYKEENNDH LDDFKAAEHA
    Predicted Reactivity
    Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 93%, Zebrafish: 79%
    Characteristics
    This is a rabbit polyclonal antibody against USP8. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human USP8
    Top Product
    Discover our top product USP8 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 1118 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    USP8 (Ubiquitin Specific Peptidase 8 (USP8))
    Alternative Name
    USP8 (USP8 Products)
    Synonyms
    HumORF8 antibody, UBPY antibody, AI574262 antibody, AW557536 antibody, Ubpy antibody, mKIAA0055 antibody, ubiquitin carboxyl-terminal hydrolase 8 antibody, ubiquitin specific peptidase 8 antibody, LOC9310109 antibody, MGYG_00369 antibody, USP8 antibody, Usp8 antibody
    Background
    USP8 is a hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. USP8 converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. USP8 catalytic activity is enhanced in the M phase. USP8 is involved in cell proliferation. USP8 is required to enter into S phase in response to serum stimulation. USP8 may regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. USP8 probably regulates the stability of STAM2 and RASGRF1. USP8 regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle.USP8 deubiquitinates EPS15 and controles tyrosine kinase stability.USP8 removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. USP8 is involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules.
    Alias Symbols: FLJ34456, HumORF8, KIAA0055, MGC129718, UBPY
    Protein Interaction Partner: VAMP8, LRIG1, TARDBP, UBC, PTEN, STAT6, TSEN2, POLD3, HTT, YWHAB, YWHAQ, YWHAE, EGFR, PTPN23, SRC, ERBB4, UBE2I, UBE2G1, FARSB, VPS4B, TRIM63, TRIM55, PJA1, USP28, TRIM54, USP21, USP15, GRAP2, CHMP4C, CHMP1B, CHMP2A, CHMP2B, RNF41, USP8, SPP1, CHMP1A, NBR
    Protein Size: 1118
    Molecular Weight
    127 kDa
    Gene ID
    9101
    NCBI Accession
    NM_005154, NP_005145
    UniProt
    P40818
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