FAS antibody (N-Term)
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- Target See all FAS Antibodies
- FAS (TNF Receptor Superfamily, Member 6 (FAS))
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Binding Specificity
- N-Term
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Reactivity
- Human, Pig, Goat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FAS antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- GLHHDGQFCH KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK
- Predicted Reactivity
- Goat: 100%, Human: 100%, Pig: 93%
- Characteristics
- This is a rabbit polyclonal antibody against FAS. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human FAS
- Top Product
- Discover our top product FAS Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 335 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- FAS (TNF Receptor Superfamily, Member 6 (FAS))
- Alternative Name
- FAS (FAS Products)
- Synonyms
- ALPS1A antibody, APO-1 antibody, APT1 antibody, CD95 antibody, FAS1 antibody, FASTM antibody, TNFRSF6 antibody, AI196731 antibody, APO1 antibody, TNFR6 antibody, Tnfrsf6 antibody, lpr antibody, Fas cell surface death receptor antibody, Fas (TNF receptor superfamily member 6) antibody, FAS antibody, Fas antibody, fas antibody
- Background
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FAS is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
Alias Symbols: ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
Protein Interaction Partner: FADD, CAV1, FAS, APOA5, TMX1, UBQLN1, MBD4, TP63, TCAP, BAG6, UBC, HNRNPC, GADD45A, CCND3, ATP6V0B, SQSTM1, Ube2i, PRAM1, RARA, PML, DAXX, FASLG, TRADD, MAP3K5, BMX, Traf1, FAF1, FAF2, TRAF3, KRIT1, TNF, BRE, LRIF1, FEM1B, FBF1, FAIM2, CASP8AP2, C14orf1,
Protein Size: 335 - Molecular Weight
- 36 kDa
- Gene ID
- 355
- NCBI Accession
- NM_000043, NP_000034
- UniProt
- P25445
- Pathways
- p53 Signaling, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
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