CASP5 antibody (Middle Region)

Catalog No. ABIN2787906

Product Details anti-CASP5 Antibody

Target: CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))

Binding Specificity: Middle Region

Reactivity: Human, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CASP5 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VIIVQACRGE KHGELWVRDS PASLALISSQ SSENLEADSV CKIHEEKDFI

Predicted Reactivity: Cow: 83%, Guinea Pig: 82%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against CASP5. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CASP5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 376 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CASP5

Target: CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))

Alternative Name: CASP5 (CASP5 Products)

Synonyms: ICE(rel)III antibody, ICEREL-III antibody, ICH-3 antibody, CASP5 antibody, caspase 5 antibody, caspase-5 antibody, CASP5 antibody, LOC100437308 antibody

Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein, this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.
Alias Symbols: ICE(rel)III, ICEREL-III, ICH-3, MGC141966
Protein Interaction Partner: PPHLN1, NLRP1, CASP5, MAX,
Protein Size: 376

Molecular Weight: 43 kDa

Gene ID: 838

NCBI Accession: NM_001136109, NP_001129581

UniProt: P51878

Pathways: Inflammasome