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CASP5 antibody (Middle Region)

CASP5 Reactivity: Human, Cow, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2787906
  • Target See all CASP5 Antibodies
    CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))
    Binding Specificity
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 43
    • 8
    • 6
    • 1
    • 1
    • 1
    • 1
    Human, Cow, Guinea Pig
    Host
    • 40
    • 3
    Rabbit
    Clonality
    • 33
    • 10
    Polyclonal
    Conjugate
    • 26
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This CASP5 antibody is un-conjugated
    Application
    • 25
    • 15
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    VIIVQACRGE KHGELWVRDS PASLALISSQ SSENLEADSV CKIHEEKDFI
    Predicted Reactivity
    Cow: 83%, Guinea Pig: 82%, Human: 100%
    Characteristics
    This is a rabbit polyclonal antibody against CASP5. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human CASP5
    Top Product
    Discover our top product CASP5 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 376 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))
    Alternative Name
    CASP5 (CASP5 Products)
    Synonyms
    ICE(rel)III antibody, ICEREL-III antibody, ICH-3 antibody, CASP5 antibody, caspase 5 antibody, caspase-5 antibody, CASP5 antibody, LOC100437308 antibody
    Background
    This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein, this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.
    Alias Symbols: ICE(rel)III, ICEREL-III, ICH-3, MGC141966
    Protein Interaction Partner: PPHLN1, NLRP1, CASP5, MAX,
    Protein Size: 376
    Molecular Weight
    43 kDa
    Gene ID
    838
    NCBI Accession
    NM_001136109, NP_001129581
    UniProt
    P51878
    Pathways
    Inflammasome
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