Thrombopoietin antibody (Middle Region)

Catalog No. ABIN2787808

Product Details anti-Thrombopoietin Antibody

Target: Thrombopoietin (THPO)

Binding Specificity: Middle Region

Reactivity: Human, Dog, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Thrombopoietin antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: NLQPGYSPSP THPPTGQYTL FPLPPTLPTP VVQLHPLLPD PSAPTPTPTS

Predicted Reactivity: Dog: 83%, Human: 100%, Rabbit: 90%

Characteristics: This is a rabbit polyclonal antibody against THPO. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human THPO

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 353 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-Thrombopoietin antibody (ABIN2787808)

Baker, Gray, Wright, Fitzsimons, Nimmo, Lowry, Mutrie,: "The effect of a pedometer-based community walking intervention "Walking for Wellbeing in the West" on physical activity levels and health outcomes: a 12-week randomized controlled trial." in: The international journal of behavioral nutrition and physical activity, Vol. 5, pp. 44, (2008) (PubMed).

Target Details for Thrombopoietin

Target: Thrombopoietin (THPO)

Alternative Name: THPO (THPO Products)

Background: Megakaryocytopoiesis is the cellular development process that leads to platelet production. THPO is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. THPO is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene.Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC163194, MGDF, MKCSF, ML, MPLLG, TPO
Protein Interaction Partner: APH1A, NUMBL, EP300, MPL,
Protein Size: 353

Molecular Weight: 35 kDa

Gene ID: 7066

NCBI Accession: NM_000460, NP_000451

UniProt: P40225

Pathways: JAK-STAT Signaling, Hormone Activity