FN3KRP antibody (N-Term)

Catalog No. ABIN2787771

Product Details anti-FN3KRP Antibody

Target: FN3KRP (Fructosamine 3 Kinase Related Protein (FN3KRP))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Zebrafish (Danio rerio), Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FN3KRP antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MDPGDPAGDP AAGERHRMGR DPLLLLQALQ TLWSTRERKQ LREEAWRGFA

Predicted Reactivity: Cow: 86%, Dog: 86%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 93%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against FN3KRP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FN3KRP

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 309 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-FN3KRP antibody (ABIN2787771)

Szwergold, Manevich, Payne, Loomes: "Fructosamine-3-kinase-related-protein phosphorylates glucitolamines on the C-4 hydroxyl: novel substrate specificity of an enigmatic enzyme." in: Biochemical and biophysical research communications, Vol. 361, Issue 4, pp. 870-5, (2007) (PubMed).

Target Details for FN3KRP

Target: FN3KRP (Fructosamine 3 Kinase Related Protein (FN3KRP))

Alternative Name: FN3KRP (FN3KRP Products)

Synonyms: FN3KL antibody, FN3K-RP antibody, fn3k antibody, fn3kl antibody, MGC145992 antibody, DKFZP469K211 antibody, RGD1304570 antibody, zgc:101634 antibody, fructosamine 3 kinase related protein antibody, fructosamine-3-kinase-related protein antibody, FN3KRP antibody, Fn3krp antibody, fn3krp antibody

Background: FN3KRP phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation.FN3KRP and FN3K (MIM 608425) protect proteins from nonenzymatic glycation by phosphorylating the modified amino acid. This phosphorylation destabilizes the sugar-amine linkage and leads to spontaneous decomposition (Conner et al., 2004 [PubMed 15381090]).[supplied by OMIM].
Alias Symbols: FLJ12171, FN3KL
Protein Interaction Partner: APP, CUL3, CUL4B, UBC, USP43,
Protein Size: 309

Molecular Weight: 34 kDa

Gene ID: 79672

NCBI Accession: NM_024619, NP_078895

UniProt: Q9HA64