SPTAN1 antibody (N-Term)

Catalog No. ABIN2787729

Product Details anti-SPTAN1 Antibody

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Pig, Dog, Horse, Zebrafish (Danio rerio), Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPTAN1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Sequence: MDPSGVKVLE TAEDIQERRQ QVLDRYHRFK ELSTLRRQKL EDSYRFQFFQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against SPTAN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SPTAN1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 2472 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SPTAN1

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Alternative Name: SPTAN1 (SPTAN1 Products)

Background: Fodrin (SPTAN1), which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Alias Symbols: (ALPHA)II-SPECTRIN, FLJ44613, NEAS, EIEE5, SPTA2
Protein Interaction Partner: SUMO3, CEP57, VCP, CEP76, STAU1, UBC, MDM2, RPA3, RPA2, RPA1, ZBTB1, EHBP1L1, NUP188, GPHN, PPP4R1, PPFIA1, PLS1, FAU, CRYZ, RPS24, PTBP1, SAV1, MAPK9, CASP7, CASP3, UBD, CAPN1, PAN2, SVIL, Tes, UBL4A, MLH1, HSP90AB1, HSP90AA1, GRIN2B, GRIN2A, GRIN1, ESR1
Protein Size: 2472

Molecular Weight: 272 kDa

Gene ID: 6709

NCBI Accession: NM_003127, NP_003118

UniProt: Q13813

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization