PNPO antibody (N-Term)

Catalog No. ABIN2787718

Product Details anti-PNPO Antibody

Target: PNPO (Pyridoxamine 5'-Phosphate Oxidase (PNPO))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PNPO antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PMRKSYRGDR EAFEETHLTS LDPVKQFAAW FEEAVQCPDI GEANAMCLAT

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PNPO. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PNPO

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 261 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-PNPO antibody (ABIN2787718)

Song, Ueno, Numata, Iga, Shibuya-Tayoshi, Nakataki, Tayoshi, Yamauchi, Sumitani, Tomotake, Tada, Tanahashi, Itakura, Ohmori: "Association between PNPO and schizophrenia in the Japanese population." in: Schizophrenia research, Vol. 97, Issue 1-3, pp. 264-70, (2007) (PubMed).

Target Details for PNPO

Target: PNPO (Pyridoxamine 5'-Phosphate Oxidase (PNPO))

Alternative Name: PNPO (PNPO Products)

Background: PNPO catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine.Vitamin B6, or pyridoxal 5-prime-phosphate (PLP), is critical for normal cellular function, and some cancer cells have notable differences in vitamin B6 metabolism compared to their normal counterparts. The rate-limiting enzyme in vitamin B6 synthesis is pyridoxine-5-prime-phosphate (PNP) oxidase (PNPO, EC 1.4.3.5).[supplied by OMIM].
Alias Symbols: FLJ10535, PDXPO
Protein Interaction Partner: UBC, LPP, APP, ELAVL1,
Protein Size: 261

Molecular Weight: 29 kDa

Gene ID: 55163

NCBI Accession: NM_018129, NP_060599

UniProt: Q9NVS9