Dynamitin antibody (N-Term)
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- Target See all Dynamitin (DCTN2) Antibodies
- Dynamitin (DCTN2) (Dynactin 2 (p50) (DCTN2))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat, Rabbit, Cow, Dog, Horse, Guinea Pig, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Dynamitin antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- ADPKYADLPG IARNEPDVYE TSDLPEDDQA EFDAFAQELE ELTSTSVEHI
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
- Characteristics
- This is a rabbit polyclonal antibody against DCTN2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human DCTN2
- Top Product
- Discover our top product DCTN2 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 406 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Dynamitin (DCTN2) (Dynactin 2 (p50) (DCTN2))
- Alternative Name
- DCTN2 (DCTN2 Products)
- Synonyms
- DCTN2 antibody, dctn2 antibody, dctn50 antibody, dynamitin antibody, rbp50 antibody, CG8269 antibody, DMN antibody, Dmel\\CG8269 antibody, P50 antibody, dDyn antibody, dmn antibody, dyna antibody, l(2)k16109 antibody, l(2)k16218 antibody, p50 antibody, p50/Dmn antibody, p50/dynamitin antibody, 2310042E05Rik antibody, C130077D06Rik antibody, C87049 antibody, DCTN-50 antibody, GMP23-48K antibody, RBP50 antibody, DCTN50 antibody, DYNAMITIN antibody, zgc:63867 antibody, dynactin subunit 2 antibody, dynactin subunit 2 S homeolog antibody, Dynactin 2, p50 subunit antibody, dynactin 2 antibody, dynactin 2 (p50) antibody, dynactin subunit 2 L homeolog antibody, DCTN2 antibody, dctn2.S antibody, DCTN2-p50 antibody, dctn2 antibody, Dctn2 antibody, dctn2.L antibody
- Background
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DCTN2 is a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place.This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: DCTN50, DYNAMITIN, RBP50
Protein Interaction Partner: KIFC3, CCDC172, HAUS1, BLOC1S6, DCTN2, BICD2, DYNC1I1, DCTN1, UBC, FLNB, NUP43, LEO1, SEH1L, ACTR10, DCTN4, DCTN3, ACTR1A, ACTR1B, RABEP1, LMNB1, GADD45A, KPNA2, SMURF1, DYNLRB1, STRN4, RANBP9, TPM4, SNRPA1, PSMD4, PSMD1, PSMC4, PSMC2, POLR2D, POLR2A, MCM
Protein Size: 406 - Molecular Weight
- 45 kDa
- Gene ID
- 10540
- NCBI Accession
- NM_006400, NP_006391
- UniProt
- Q13561
- Pathways
- M Phase, Ribonucleoprotein Complex Subunit Organization
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