USP22 antibody (Middle Region)

Catalog No. ABIN2787647

Product Details anti-USP22 Antibody

Target: USP22 (Ubiquitin Specific Peptidase 22 (USP22))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Mouse, Horse, Dog, Guinea Pig, Rabbit, Cow, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP22 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PSSCLVCEMS SLFQEFYSGH RSPHIPYKLL HLVWTHARHL AGYEQQDAHE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against USP22. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human USP22

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 525 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for USP22

Target: USP22 (Ubiquitin Specific Peptidase 22 (USP22))

Alternative Name: USP22 (USP22 Products)

Synonyms: USP3L antibody, AI427806 antibody, zgc:136342 antibody, usp22 antibody, usp22 b antibody, usp22-B antibody, usp22-a antibody, usp3l antibody, ubiquitin specific peptidase 22 antibody, ubiquitin specific peptidase 22 S homeolog antibody, USP22 antibody, Usp22 antibody, usp22 antibody, usp22.S antibody

Background: USP22 is a subunit of the SAGA transcriptional cofactor complex. It deubiquitylates histone H2B and is recruited to specific genes by activators like Myc. USP22 is needed for cell cycle progression. It deubiquitylates histone H2A in addition to H2B. Altered mRNA expression is associated with therapy failure and death in patients multiple types of cancer.
Alias Symbols: KIAA1063, USP3L
Protein Interaction Partner: UBC, AASDHPPT, STAT3, TAF10, TADA2A, ATXN7, MYC, KAT2A, TRRAP, TAF9B, HIST1H2BD, TADA3, SUMO1, NFATC2, SIRT1, ATXN7L3, FUBP1, HIST2H2BE, HIST2H2AC, MRPL44, ATXN7L3B, USP27X, KIF7, KLHL23, ATXN7L2, TADA1, CCDC101, TADA2B, ENY2, SUPT20H, TAF5L, SND1, CNOT10
Protein Size: 525

Molecular Weight: 60 kDa

Gene ID: 23326

NCBI Accession: NM_015276, NP_056091

UniProt: Q9UPT9