TNKS1BP1 antibody (Middle Region)

Catalog No. ABIN2787645

Product Details anti-TNKS1BP1 Antibody

Target: TNKS1BP1 (Tankyrase 1 Binding Protein 1, 182kDa (TNKS1BP1))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNKS1BP1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: DGEASQTEDV DGTWGSSAAR WSDQGPAQTS RRPSQGPPAR SPSQDFSFIE

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against TNKS1BP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TNKS1BP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1729 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TNKS1BP1

Target: TNKS1BP1 (Tankyrase 1 Binding Protein 1, 182kDa (TNKS1BP1))

Alternative Name: TNKS1BP1 (TNKS1BP1 Products)

Background: TNKS-1 mRNA in urine sediment from patients with bladder TCC correlated with tumor stage, and higher preoperative levels were associated with increased risk of early recurrence. Tankyrase-1 is required in the assembly of bipolar spindles and the spindle-pole protein NuMA as a substrate for covalent modification by tankyrase-1. Data also show that tankyrase 1 inhibition in human cancer cells enhances telomere shortening by a telomerase inhibitor and hastens cell death.
Alias Symbols: FLJ45975, KIAA1741, TAB182
Protein Interaction Partner: UBC, RNF219, SPC25, RABGEF1, DCTN3, SPTBN1, NLK, CSNK2A1, CNOT6L, CNOT6, VCP, HNRNPK, DYNC1H1, CBX3, SIRT7, TSG101, Cnot3, Capza1, TNKS2, TNKS,
Protein Size: 1729

Molecular Weight: 190 kDa

Gene ID: 85456

NCBI Accession: NM_033396, NP_203754

UniProt: Q9C0C2