TUB antibody (N-Term)

Catalog No. ABIN2787451

Product Details anti-TUB Antibody

Target: TUB (Tubby Homolog (TUB))

Binding Specificity: N-Term

Reactivity: Human, Horse, Dog, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TUB antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MGARTPLPSF WVSFFAETGI LFPGGTPWPM GSQHSKQHRK PGPLKRGHRR

Predicted Reactivity: Dog: 83%, Horse: 92%, Human: 100%, Rabbit: 91%

Characteristics: This is a rabbit polyclonal antibody against TUB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TUB

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 561 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TUB

Target: TUB (Tubby Homolog (TUB))

Alternative Name: TUB (TUB Products)

Synonyms: rd5 antibody, tubby antibody, MGC79522 antibody, TUB antibody, MGC80126 antibody, MGC84061 antibody, tub antibody, tubby bipartite transcription factor antibody, tubby bipartite transcription factor S homeolog antibody, tub antibody, TUB antibody, tub.S antibody, Tub antibody

Background: TUB functions in signal transduction from heterotrimeric G protein-coupled receptors. It could be involved in the hypothalamic regulation of body weight.This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene.
Alias Symbols: rd5
Protein Interaction Partner: UBC, SUV420H2, GNAQ, SRC, ABL1, PLCG1, PIK3R1, LCK, JAK2, IRS1, GRB2,
Protein Size: 561

Molecular Weight: 62 kDa

Gene ID: 7275

NCBI Accession: NM_003320, NP_003311

UniProt: P50607

Pathways: RTK Signaling, Sensory Perception of Sound