MFN1 antibody (Middle Region)

Catalog No. ABIN2787347

Product Details anti-MFN1 Antibody

Target: MFN1 (Mitofusin 1 (MFN1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Horse, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MFN1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: QVDITQKQLE EEIARLPKEI DQLEKIQNNS KLLRNKAVQL ENELENFTKQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 86%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against MFN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MFN1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 741 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-MFN1 antibody (ABIN2787347)

Bonala, McFarlane, Ang, Lim, Lee, Chua, Lokireddy, Sreekanth, Leow, Meng, Shyong, Lee, Gluckman, Sharma, Kambadur: "Pid1 induces insulin resistance in both human and mouse skeletal muscle during obesity." in: Molecular endocrinology (Baltimore, Md.), Vol. 27, Issue 9, pp. 1518-35, (2013) (PubMed).

Papanicolaou, Khairallah, Ngoh, Chikando, Luptak, OShea, Riley, Lugus, Colucci, Lederer, Stanley, Walsh: "Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytes." in: Molecular and cellular biology, Vol. 31, Issue 6, pp. 1309-28, (2011) (PubMed).

Target Details for MFN1

Target: MFN1 (Mitofusin 1 (MFN1))

Alternative Name: MFN1 (MFN1 Products)

Synonyms: mfn1 antibody, zgc:66150 antibody, mitofusin-1 antibody, MFN1 antibody, MFN2 antibody, hfzo1 antibody, hfzo2 antibody, 2310002F04Rik antibody, 6330416C07Rik antibody, D3Ertd265e antibody, HR2 antibody, mKIAA4032 antibody, Fzo1b antibody, mitofusin 1b antibody, mitofusin 1 antibody, mitofusin 1 S homeolog antibody, mfn1b antibody, MFN1 antibody, mfn1.S antibody, mfn1 antibody, Mfn1 antibody

Background: The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.
Alias Symbols: DKFZp762F247, FLJ20693, MGC41806, hfzo1, hfzo2
Protein Interaction Partner: PARK2, MARCH5, UBC, TER94, MAVS, CCNB1, ILF2, BAK1,
Protein Size: 741

Molecular Weight: 84 kDa

Gene ID: 55669

NCBI Accession: NM_033540, NP_284941

UniProt: Q8R4Z9