TMPRSS3 antibody (N-Term)

Catalog No. ABIN2787338

Product Details anti-TMPRSS3 Antibody

Target: TMPRSS3 (Transmembrane Protease, Serine 3 (TMPRSS3))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Cow, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMPRSS3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MGENDPPAVE APFSFRSLFG LDDLKISPVA PDADAVAAQI LSLLPLKFFP

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against TMPRSS3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TMPRSS3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 344 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-TMPRSS3 antibody (ABIN2787338)

Spellman, Ahmed, Dubach, Gardiner: "Expression of trisomic proteins in Down syndrome model systems." in: Gene, Vol. 512, Issue 2, pp. 219-25, (2012) (PubMed).

Target Details for TMPRSS3

Target: TMPRSS3 (Transmembrane Protease, Serine 3 (TMPRSS3))

Alternative Name: TMPRSS3 (TMPRSS3 Products)

Synonyms: TMPRSS3 antibody, DKFZp469L1528 antibody, DFNB10 antibody, DFNB8 antibody, ECHOS1 antibody, TADG12 antibody, transmembrane protease, serine 3 antibody, TMPRSS3 antibody, Tmprss3 antibody

Background: This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, a LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described.
Alias Symbols: DFNB10, DFNB8, ECHOS1, TADG12
Protein Interaction Partner: TMED7, UBC, RXRA, EEF1A1,
Protein Size: 344

Molecular Weight: 37 kDa

Gene ID: 64699

NCBI Accession: NM_032405, NP_115781

UniProt: Q8WY52

Pathways: Sensory Perception of Sound