GREM2 antibody (N-Term)

Catalog No. ABIN2787313

Product Details anti-GREM2 Antibody

Target: GREM2 (Gremlin 2 (GREM2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Guinea Pig, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GREM2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MFWKLSLSLF LVAVLVKVAE ARKNRPAGAI PSPYKDGSSN NSERWQHQIK

Predicted Reactivity: Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against GREM2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GREM2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 168 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GREM2

Target: GREM2 (Gremlin 2 (GREM2))

Alternative Name: GREM2 (GREM2 Products)

Synonyms: prdc antibody, zgc:112207 antibody, RGD1560008 antibody, Gremlin2 antibody, Prdc antibody, CKTSF1B2 antibody, DAND3 antibody, PRDC antibody, gremlin 2, DAN family BMP antagonist antibody, gremlin 2, DAN family BMP antagonist b antibody, gremlin 2, cysteine knot superfamily antibody, GREM2 antibody, grem2b antibody, grem2 antibody, Grem2 antibody

Background: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation.
Alias Symbols: CKTSF1B2, DAND3, PRDC
Protein Interaction Partner: BMP4, BMP2,
Protein Size: 168

Molecular Weight: 17 kDa

Gene ID: 64388

NCBI Accession: NM_022469, NP_071914

UniProt: Q9H772