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RPRD1B antibody (C-Term)
RPRD1B
Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-RPRD1B Antibody
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Target
See all RPRD1B Antibodies
RPRD1B
(Regulation of Nuclear Pre-mRNA Domain Containing 1B (RPRD1B))
Binding Specificity
All epitopes for RPRD1B antibodies
C-Term
Reactivity
All reactivities for RPRD1B antibodies
Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig
Host
All hosts for RPRD1B antibodies
Rabbit
Clonality
All clonalities for RPRD1B antibodies
Polyclonal
Conjugate
All conjugates for RPRD1B antibodies
This RPRD1B antibody is un-conjugated
Application
All applications for RPRD1B antibodies
Western Blotting (WB)
Sequence
QERSVYGGEF IQQLKLSMED SKSPPPKAAE EKKSLKRTFQ QIQEEEDDDY
Predicted Reactivity
Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
Characteristics
This is a rabbit polyclonal antibody against Rprd1b. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Rprd1b
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Discover our top product RPRD1B Primary Antibody
Alternatives
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anti-Regulation of Nuclear Pre-mRNA Domain Containing 1B (RPRD1B) (AA 143-192) antibody
RPRD1B
Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig, Chicken, Bat, Hamster, Monkey, Pig
WB
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeat freeze-thaw cycles.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for RPRD1B
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Target
RPRD1B
(Regulation of Nuclear Pre-mRNA Domain Containing 1B (RPRD1B))
Alternative Name
Rprd1b (RPRD1B Products )
Synonyms
fb23h08 antibody, zgc:55687 antibody, wu:fb23h08 antibody, rprd1ba antibody, MGC130705 antibody, C13H20ORF77 antibody, C20orf77 antibody, CREPT antibody, NET60 antibody, dJ1057B20.2 antibody, 2610304G08Rik antibody, 2810446G03Rik antibody, Crept antibody, RGD1304782 antibody, regulation of nuclear pre-mRNA domain containing 1B antibody, regulation of nuclear pre-mRNA domain containing 1B L homeolog antibody, rprd1b antibody, rprd1b.L antibody, RPRD1B antibody, Rprd1b antibody
Background
Rprd1b interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. It is a transcriptional regulator which enhances expression of CCND1. It promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. It prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. It also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Rprd1b promotes cell proliferation. Alias Symbols: 2610304G08Rik, 2810446G03Rik, Crept Protein Size: 224
Molecular Weight
24 kDa
Gene ID
70470
NCBI Accession
NM_027434 , NP_081710
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