CALCOCO1 antibody (N-Term)

Catalog No. ABIN2787240

Product Details anti-CALCOCO1 Antibody

Target: CALCOCO1 (Calcium Binding and Coiled-Coil Domain 1 (CALCOCO1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CALCOCO1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ESTTDGSPIH TSVQFQASYL PKPGAQLYQF RYVNRQGQVC GQSPPFQFRE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against CALCOCO1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CALCOCO1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 691 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CALCOCO1

Target: CALCOCO1 (Calcium Binding and Coiled-Coil Domain 1 (CALCOCO1))

Alternative Name: CALCOCO1 (CALCOCO1 Products)

Synonyms: Cocoa antibody, calphoglin antibody, fa11a10 antibody, wu:fa11a10 antibody, CALCOCO1 antibody, Xdsg antibody, cocoa antibody, dsgc antibody, pp13275 antibody, 1810009B06Rik antibody, Gcap11 antibody, mKIAA1536 antibody, calcium binding and coiled-coil domain 1 antibody, calcium binding and coiled-coil domain 1a antibody, calcium binding and coiled-coil domain 1 S homeolog antibody, calcium binding and coiled-coil domain 1 L homeolog antibody, calcium binding and coiled coil domain 1 antibody, CALCOCO1 antibody, calcoco1a antibody, calcoco1.S antibody, calcoco1.L antibody, Calcoco1 antibody

Background: CALCOCO1 functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR).CALCOCO1 is recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation CALCOCO1 acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. CALCOCO1 is involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. CALCOCO1 functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions.
Alias Symbols: Cocoa, KIAA1536, PP13275, calphoglin
Protein Interaction Partner: CWF19L2, CEP19, FAM161A, TBC1D15, DUSP13, ISOC1, GABARAPL2, NDC80, UBC, GRIK2, APP, APTX, EP300, CTNNB1, NEDD4, HIST1H4A, HIST1H3A, PCBD1, TBC1D17, CTNNBL1, CYTH3, SH3GL3, CRYBA2, CREBBP, MAPK1, KRT15, IPP, FOSL1,
Protein Size: 691

Molecular Weight: 77 kDa

Gene ID: 57658

NCBI Accession: NM_020898, NP_065949

UniProt: Q9P1Z2

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Chromatin Binding