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TDP1 antibody (C-Term)
TDP1
Reactivity: Human, Mouse, Rat, Horse, Cow, Guinea Pig, Dog, Rabbit, Zebrafish (Danio rerio)
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-TDP1 Antibody
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Target
See all TDP1 Antibodies
TDP1
(Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
Binding Specificity
All epitopes for TDP1 antibodies
C-Term
Reactivity
All reactivities for TDP1 antibodies
Human, Mouse, Rat, Horse, Cow, Guinea Pig, Dog, Rabbit, Zebrafish (Danio rerio)
Host
All hosts for TDP1 antibodies
Rabbit
Clonality
All clonalities for TDP1 antibodies
Polyclonal
Conjugate
All conjugates for TDP1 antibodies
This TDP1 antibody is un-conjugated
Application
All applications for TDP1 antibodies
Western Blotting (WB)
Sequence
GRPPGKSAVP LHLIYPSVEN VRTSLEGYPA GGSLPYSIQT AEKQRWLHSY
Predicted Reactivity
Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 100%
Characteristics
This is a rabbit polyclonal antibody against Tdp1. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of mouse TDP1
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeat freeze-thaw cycles.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for TDP1
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Target
TDP1
(Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
Alternative Name
Tdp1 (TDP1 Products )
Synonyms
2810481F14Rik antibody, 4921509N21Rik antibody, AI838772 antibody, AW493413 antibody, E430034L06Rik antibody, MLZ-501 antibody, SCAN1 antibody, tdp1 antibody, MGC83708 antibody, TDP1 antibody, F8M21.60 antibody, F8M21_60 antibody, tyrosyl-DNA phosphodiesterase 1 antibody, tyrosyl-DNA phosphodiesterase 1 antibody, tyrosyl-DNA Phosphodiesterase (Tdp1) antibody, tyrosyl-DNA phosphodiesterase 1 L homeolog antibody, tyrosyl-DNA phosphodiesterase-like protein antibody, TDP1 antibody, Tc00.1047053511191.10 antibody, Tdp1 antibody, tdp1.L antibody, tdp1 antibody, PTRG_11198 antibody, MCYG_02121 antibody, MGYG_03035 antibody
Background
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. Protein Size: 609
Molecular Weight
66 kDa
Gene ID
55775
NCBI Accession
NM_001008744 , NP_001008744
UniProt
Q9NUW8
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