PRR5 antibody (C-Term)

Catalog No. ABIN504071

Product Details anti-PRR5 Antibody

Target: PRR5 (Proline Rich 5 (Renal) (PRR5))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRR5 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SPAPHSGPCP SRLYPTTQPP EQGLDPTRSS LPRSSPENLV DQILESVDSD

Predicted Reactivity: Cow: 100%, Dog: 91%, Horse: 86%, Human: 100%, Pig: 100%

Characteristics: This is a rabbit polyclonal antibody against PRR5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PRR5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 379 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PRR5

Target: PRR5 (Proline Rich 5 (Renal) (PRR5))

Alternative Name: PRR5 (PRR5 Products)

Background: This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.
Alias Symbols: PP610, PROTOR1, PROTOR-1, FLJ20185k,
Protein Interaction Partner: MTOR, BRCA1, UBC, RICTOR, MAPKAP1, MLST8,
Protein Size: 293

Molecular Weight: 32 kDa

Gene ID: 55615

NCBI Accession: NM_001017528, NP_056181

Pathways: PI3K-Akt Signaling