PEX5 antibody (N-Term)

Catalog No. ABIN503842

Product Details anti-PEX5 Antibody

Target: PEX5 (Peroxisomal Biogenesis Factor 5 (PEX5))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Horse, Rabbit, Guinea Pig, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PEX5 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TATDRWYDEY HPEEDLQHTA SDFVAKVDDP KLANSEFLKF VRQIGEGQVS

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PEX5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PEX5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 631 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PEX5

Target: PEX5 (Peroxisomal Biogenesis Factor 5 (PEX5))

Alternative Name: PEX5 (PEX5 Products)

Background: PEX5 binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD).
Alias Symbols: PTS1R, PXR1, PTS1-BP
Protein Interaction Partner: CAPRIN2, CCDC14, TOMM7, PRR13, GDPD5, ZNF772, EP400NL, TM6SF1, ACOT8, RPL14, MKRN3, S100A6, LDHB, RANBP6, GSTK1, ZADH2, TYSND1, HSDL2, ACAD11, LONP2, PECR, HSD17B4, HOXA7, EHHADH, ECH1, CRAT, CAT, BRCA1, ACOX1, DECR2, HACL1, DHRS4, ECI2, AGPS, GNPAT, UBC,
Protein Size: 631

Molecular Weight: 70 kDa

Gene ID: 5830

NCBI Accession: NM_000319, NP_000310

Pathways: Monocarboxylic Acid Catabolic Process