PPOX antibody (N-Term)

Catalog No. ABIN2786509

Product Details anti-PPOX Antibody

Target: PPOX (Protoporphyrinogen Oxidase (PPOX))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Guinea Pig, Horse, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPOX antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SSERLGGWIR SVRGPNGAIF ELGPRGIRPA GALGARTLLL VSELGLDSEV

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PPOX. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PPOX

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 477 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-PPOX antibody (ABIN2786509)

de Vooght, van Wijk, van Solinge: "GATA-1 binding sites in exon 1 direct erythroid-specific transcription of PPOX." in: Gene, Vol. 409, Issue 1-2, pp. 83-91, (2008) (PubMed).

Target Details for PPOX

Target: PPOX (Protoporphyrinogen Oxidase (PPOX))

Alternative Name: PPOX (PPOX Products)

Background: PPOX catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX..This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified.
Alias Symbols: MGC8485, PPO, V290M, VP
Protein Interaction Partner: HNRNPD, UBC, COPS5, HAP1, PPOX, IMMT,
Protein Size: 477

Molecular Weight: 51 kDa

Gene ID: 5498

NCBI Accession: NM_000309, NP_000300

UniProt: P50336

Pathways: Synaptic Membrane, Feeding Behaviour