PPOX antibody (N-Term)

Catalog No. ABIN2786509

Product Details anti-PPOX Antibody

Target: PPOX (Protoporphyrinogen Oxidase (PPOX))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Guinea Pig, Horse, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPOX antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SSERLGGWIR SVRGPNGAIF ELGPRGIRPA GALGARTLLL VSELGLDSEV

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PPOX. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PPOX

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 477 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-PPOX antibody (ABIN2786509)

de Vooght, van Wijk, van Solinge: "GATA-1 binding sites in exon 1 direct erythroid-specific transcription of PPOX." in: Gene, Vol. 409, Issue 1-2, pp. 83-91, (2008) (PubMed).

Target Details for PPOX

Target: PPOX (Protoporphyrinogen Oxidase (PPOX))

Alternative Name: PPOX (PPOX Products)

Synonyms: PPO antibody, V290M antibody, VP antibody, Ppo antibody, BcDNA:LD41392 antibody, CG5796 antibody, Dmel\\CG5796 antibody, ESTS:9F2T antibody, zgc:123252 antibody, HEMG1 antibody, PPO1 antibody, PROTOPORPHYRINOGEN OXIDASE antibody, TC0121 antibody, hemG antibody, protoporphyrinogen oxidase antibody, Protoporphyrinogen oxidase antibody, Flavin containing amine oxidoreductase family antibody, polyphenol oxidase, chloroplastic antibody, PPOX antibody, Ppox antibody, ppox antibody, hemY antibody, TC_RS00645 antibody, Mrub_1406 antibody, Mesil_2992 antibody, Trad_0583 antibody, Calni_0746 antibody, Ocepr_1049 antibody, Tmar_0766 antibody, Intca_1907 antibody, Despr_0642 antibody, Plabr_2407 antibody, Deipr_2130 antibody, Hipma_0622 antibody, LOC110782963 antibody

Background: PPOX catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX..This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified.
Alias Symbols: MGC8485, PPO, V290M, VP
Protein Interaction Partner: HNRNPD, UBC, COPS5, HAP1, PPOX, IMMT,
Protein Size: 477

Molecular Weight: 51 kDa

Gene ID: 5498

NCBI Accession: NM_000309, NP_000300

UniProt: P50336

Pathways: Synaptic Membrane, Feeding Behaviour