Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

RHOC antibody (N-Term)

RHOC Reactivity: Human, Mouse, Rat, Dog, Rabbit, Cow, Guinea Pig, Zebrafish (Danio rerio), Horse, Saccharomyces cerevisiae, Goat, Sheep WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2786344
  • Target See all RHOC Antibodies
    RHOC (Ras Homolog Gene Family, Member C (RHOC))
    Binding Specificity
    • 9
    • 8
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 42
    • 18
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog, Rabbit, Cow, Guinea Pig, Zebrafish (Danio rerio), Horse, Saccharomyces cerevisiae, Goat, Sheep
    Host
    • 35
    • 8
    Rabbit
    Clonality
    • 36
    • 6
    Polyclonal
    Conjugate
    • 22
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RHOC antibody is un-conjugated
    Application
    • 31
    • 26
    • 15
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    VPTVFENYIA DIEVDGKQVE LALWDTAGQE DYDRLRPLSY PDTDVILMCF
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Yeast: 100%, Zebrafish: 100%
    Characteristics
    This is a rabbit polyclonal antibody against RHOC. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human RHOC
    Top Product
    Discover our top product RHOC Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 193 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Sousa, Espreafico: "Suppression subtractive hybridization profiles of radial growth phase and metastatic melanoma cell lines reveal novel potential targets." in: BMC cancer, Vol. 8, pp. 19, (2008) (PubMed).

  • Target
    RHOC (Ras Homolog Gene Family, Member C (RHOC))
    Alternative Name
    RHOC (RHOC Products)
    Synonyms
    ARHC antibody, LOC100221682 antibody, ARH9 antibody, H9 antibody, RHOH9 antibody, AI324259 antibody, Arh9 antibody, Arhc antibody, CRHOC antibody, ras homolog family member C L homeolog antibody, ras homolog family member C antibody, rhoc.L antibody, RHOC antibody, rhoc antibody, Rhoc antibody
    Background
    RHOC Is a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. RHOC is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of RHOC is associated with tumor cell proliferation and metastasis.This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
    Alias Symbols: ARH9, ARHC, H9, MGC1448, MGC61427, RHOH9
    Protein Interaction Partner: FAM65B, UBC, env, ATF2, PPP3CA, CDK2, LNX1, CAV1, CIT, ARHGAP1, RTKN, DIAPH1, ROCK1, VHL, ARHGDIA,
    Protein Size: 193
    Molecular Weight
    22 kDa
    Gene ID
    389
    NCBI Accession
    NM_175744, NP_786886
    UniProt
    P08134
    Pathways
    WNT Signaling, Cell-Cell Junction Organization
You are here:
Support