COX18 antibody (Middle Region)

Catalog No. ABIN2786331

Product Details anti-COX18 Antibody

Target: COX18 (Cytochrome C Oxidase Assembly Homolog 18 (COX18))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COX18 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LCSSFVGLSQ NLLLRSPGFR QLCRIPSTKS DSETPYKDIF AAFNTKFISR

Predicted Reactivity: Cow: 79%, Dog: 79%, Horse: 86%, Human: 100%, Mouse: 85%, Pig: 86%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against COX18. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human COX18

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 333 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for COX18

Target: COX18 (Cytochrome C Oxidase Assembly Homolog 18 (COX18))

Alternative Name: COX18 (COX18 Products)

Synonyms: COX18HS antibody, BC038311 antibody, RGD1559547 antibody, COX18 cytochrome c oxidase assembly factor L homeolog antibody, COX18, cytochrome c oxidase assembly factor antibody, cytochrome c oxidase assembly protein 18 antibody, cox18.L antibody, COX18 antibody, Cox18 antibody

Background: COX18 is required for the insertion of integral membrane proteins into the mitochondrial inner membrane. COX18 is essential for the activity and assembly of cytochrome c oxidase. COX18 plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space.COX18 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox18 protein catalyzes the insertion of the Cox2 (MTCO2, MIM 516040) C-terminal tail into the mitochondrial inner membrane, an intermediate step in the assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 [PubMed 16212937]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1248 AY957565.1 1-1248 1249-4523 AC095053.3 75071-78345 c
Alias Symbols: COX18HS, FLJ38991, MGC126733
Protein Size: 333

Molecular Weight: 37 kDa

Gene ID: 285521

NCBI Accession: NM_173827, NP_776188

UniProt: Q8N8Q8