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SPAG8 antibody (Middle Region)

SPAG8 Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2786290
  • Target See all SPAG8 Antibodies
    SPAG8 (Sperm Associated Antigen 8 (SPAG8))
    Binding Specificity
    • 15
    • 8
    • 8
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    Human, Mouse, Rat, Rabbit, Cow, Dog, Pig
    Host
    • 51
    • 4
    Rabbit
    Clonality
    • 53
    • 2
    Polyclonal
    Conjugate
    • 21
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SPAG8 antibody is un-conjugated
    Application
    • 29
    • 23
    • 13
    • 13
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    PAPTKPHDYR QEQPETFWIQ RAPQLPTWWP LPTQVPAAED YLTWKEWGFT
    Predicted Reactivity
    Cow: 79%, Dog: 93%, Human: 100%, Mouse: 100%, Pig: 86%, Rabbit: 93%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against SPAG8. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human SPAG8
    Top Product
    Discover our top product SPAG8 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 501 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Dyrbye, Broholm, Dziegiel, Laursen: "The M129V polymorphism of codon 129 in the prion gene (PRNP) in the Danish population." in: European journal of epidemiology, Vol. 23, Issue 1, pp. 23-7, (2008) (PubMed).

  • Target
    SPAG8 (Sperm Associated Antigen 8 (SPAG8))
    Alternative Name
    SPAG8 (SPAG8 Products)
    Synonyms
    BS-84 antibody, HSD-1 antibody, SMP1 antibody, SPAG3 antibody, hSMP-1 antibody, MH-SPAG8 antibody, sperm associated antigen 8 antibody, SPAG8 antibody, Spag8 antibody
    Background
    The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. SPAG8 is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa.The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.
    Alias Symbols: BS-84, HSD-1, MGC26201, SMP1, SPAG3, hSMP-1
    Protein Interaction Partner: KLHL32, DTX2, SNRPC, CSTF2, PITX1, JMJD4, WHSC1L1, KDM3B, CARM1, PRMT5, PRMT1, PRMT2, RANBP9, UBQLN4, NEDD4L, RAN,
    Protein Size: 501
    Molecular Weight
    53 kDa
    Gene ID
    26206
    NCBI Accession
    NM_172312, NP_758516
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