TMOD3 antibody (Middle Region)

Catalog No. ABIN2786043

Product Details anti-TMOD3 Antibody

Target: TMOD3 (Tropomodulin 3 (TMOD3))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Horse, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMOD3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ITNTKFCNIM GSSNGVDQEH FSNVVKGEKI LPVFDEPPNP TNVEESLKRT

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against TMOD3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TMOD3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 352 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TMOD3

Target: TMOD3 (Tropomodulin 3 (TMOD3))

Alternative Name: TMOD3 (TMOD3 Products)

Background: TMOD3 belongs to the tropomodulin family. It blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.
Alias Symbols: UTMOD
Protein Interaction Partner: UBC, PABPC1, YWHAE, PSMD9, PPP1CA, DHX15, PAN2, CSNK2A1, HNRNPUL2, PPIL3, AHCYL1, SULT1A1, PSMC4, PSMB7, NPC1, ATP6V1B1, LRRK2, FBXO25, ISG15, ARRB2, ARRB1, ELAVL1, SUMO2, DUSP23, TNFSF11, MAP1LC3B, Poc1b, Tubgcp3, Sass6, Trim69, Stag2, Pafah1b1, Erh, Cdk
Protein Size: 352

Molecular Weight: 39 kDa

Gene ID: 29766

NCBI Accession: NM_014547, NP_055362

UniProt: Q9NYL9

Pathways: Regulation of Actin Filament Polymerization