ITGB3BP antibody (N-Term)

Catalog No. ABIN2785998

Product Details anti-ITGB3BP Antibody

Target: ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITGB3BP antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TGTCQMSLFA SPTSSEEQKH RNGLSNEKRK KLNHPSLTES KESTTKDNDE

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against ITGB3BP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ITGB3BP

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 177 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ITGB3BP

Target: ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))

Alternative Name: ITGB3BP (ITGB3BP Products)

Synonyms: CENP-R antibody, CENPR antibody, HSU37139 antibody, NRIF3 antibody, TAP20 antibody, 4930471O16Rik antibody, AU022583 antibody, integrin subunit beta 3 binding protein antibody, integrin beta 3 binding protein (beta3-endonexin) antibody, ITGB3BP antibody, Itgb3bp antibody

Background: ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
Alias Symbols: CENP-R, CENPR, HSU37139, NRIF3, TAP20
Protein Interaction Partner: PIH1D2, UBR7, ARFIP2, COL4A3BP, KIFC3, KDM1A, UBC, APP, CENPP, CENPO, SVIL, MAPK6, ACTN2, MTA1, ITGB3BP, DDX24, RECQL5, RXRA, ITGB3, NFKB1, ITGB5, ESR1, CCNA2, THRA, RELA, RXRG,
Protein Size: 177

Molecular Weight: 20 kDa

Gene ID: 23421

NCBI Accession: NM_014288, NP_055103

UniProt: Q13352

Pathways: Neurotrophin Signaling Pathway