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VPS4A antibody (N-Term)

VPS4A Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Horse, Guinea Pig, Zebrafish (Danio rerio) WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2785950
  • Target See all VPS4A Antibodies
    VPS4A (Vacuolar Protein Sorting-Associated Protein 4A (VPS4A))
    Binding Specificity
    • 15
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 33
    • 22
    • 15
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Rabbit, Cow, Dog, Horse, Guinea Pig, Zebrafish (Danio rerio)
    Host
    • 31
    • 2
    Rabbit
    Clonality
    • 33
    Polyclonal
    Conjugate
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This VPS4A antibody is un-conjugated
    Application
    • 26
    • 13
    • 13
    • 7
    • 5
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    YFLHAIKYEA HSDKAKESIR AKCVQYLDRA EKLKDYLRSK EKHGKKPVKE
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
    Characteristics
    This is a rabbit polyclonal antibody against VPS4A. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human VPS4A
    Top Product
    Discover our top product VPS4A Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 437 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Taylor, Hanson, Kielian: "Ubiquitin depletion and dominant-negative VPS4 inhibit rhabdovirus budding without affecting alphavirus budding." in: Journal of virology, Vol. 81, Issue 24, pp. 13631-9, (2007) (PubMed).

  • Target
    VPS4A (Vacuolar Protein Sorting-Associated Protein 4A (VPS4A))
    Alternative Name
    VPS4A (VPS4A Products)
    Synonyms
    vsp4 antibody, SKD1 antibody, SKD1A antibody, SKD2 antibody, VPS4 antibody, VPS4-1 antibody, zgc:153907 antibody, 4930589C15Rik antibody, AI325971 antibody, AW553189 antibody, vacuolar protein sorting 4 homolog A antibody, vacuolar sorting protein 4 antibody, vacuolar protein sorting 4 homolog A L homeolog antibody, vacuolar protein sorting 4a homolog A (S. cerevisiae) antibody, vacuolar protein sorting 4A antibody, VPS4A antibody, TP03_0351 antibody, vps4a antibody, vps4a.L antibody, Vps4a antibody
    Background
    VPS4A is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast.The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16, the gene for the other resides on chromosome 18. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: FLJ22197, SKD1, SKD2, VPS4, VPS4-1, SKD1A
    Protein Interaction Partner: FBXO6, UBC, CFTR, KCND3, CHMP4B, CHMP1B, CHMP4A, CHMP2A, VPS4A, CHMP1A, CHMP4C, gag, VTA1, CHMP3, CHMP5, HGS, NPC1, BABAM1, VPS4B, RND2,
    Protein Size: 437
    Molecular Weight
    49 kDa
    Gene ID
    27183
    NCBI Accession
    NM_013245, NP_037377
    UniProt
    Q9UN37
    Pathways
    Microtubule Dynamics, CXCR4-mediated Signaling Events
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